Simon works as an anaesthesiologist at Auckland City Hospital, a diving physician at North Shore Hospital (Auckland), and is Professor of Anaesthesiology at the University of Auckland. He is widely published with two books and over 170 scientific journal papers or book chapters. He co-authored the 5th edition of 'Diving and Subaquatic Medicine' and the Hyperbaric and Diving Medicine chapters in the last four editions of Harrison’s Principles of Internal Medicine. He has twice been Vice President of the Undersea and Hyperbaric Medicine Society (USA) and in 2010 received the society’s Behnke Award for scientific contributions to diving medicine. 
He has been Editor-in-Chief of Diving and Hyperbaric Medicine Journal since 2019.
Simon has a long career in sport, scientific, commercial, and military diving. He has participated in cutting edge wreck and cave diving expeditions spanning many years. In 2002 he performed the deepest dive to a shipwreck at that time. In February 2023 he was a member of the Wet Mules expedition to the Pearse Resurgence cave in New Zealand where a 230 m dive was conducted using hydrogen as a breathing gas on a deep dive for the first time in over 30 years. He was conferred Fellowship of the Explorers’ Club of New York in 2006, and was the Rolex Diver of the Year in 2015.
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